Short answer: No — P0260 code is NOT caused by DPF, EGR, or DEF systems.
Check All GM Duramax Code Explain here.
What Does P0260 Code Mean?
On L5P Duramax, code P0260 = Injection Pump Fuel Metering Control "B" Intermittent (Cam/Rotor/Injector).

In plain English, your truck's ECU tried to “learn” how much fuel each injector should deliver, but one (or more) is outside the acceptable range.
What Might Cause P0260?
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Fuel injector imbalance (one injector flowing too much or too little)
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Failing or sticking injector
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Fuel contamination
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High-pressure fuel system issues (pump or rail)
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Incorrect injector calibration data
Can a Bad Tune Trigger P0260?
Maybe—but indirectly. If the tuning is poorly calibrated, or uses incorrect injector data, or even worse, it didn't match to your truck at all, then it might mess with injector balance calculations and trigger the code.
Again, however, this code is not relevant to DPF/EGR/DEF removal itself.
What You Should Check
If you’re seeing P0260, follow the steps below:
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Check injector balance rates
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Inspect fuel quality (contamination is common)
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Verify injector codes are programmed correctly
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Look at rail pressure and pump health
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Make sure your tune is clean and properly matched
Emission Codes vs. Injector-Related Codes
If your truck is deleted and throwing multiple codes, it’s easy to assume everything is emissions-related.
But here’s the key:
👉 DPF / EGR / DEF issues trigger emissions codes (P20xx, P24xx, etc.)
👉 P0260 is strictly tied to fueling and injector learning
E.g. DPF / EGR / DEF related code
P0400 Exhaust Gas Recirculation Flow Malfunction
P0401 Exhaust Gas Recirculation Flow Insufficient Detected
P0402 Exhaust Gas Recirculation Flow Excessive Detected
P0403 Exhaust Gas Recirculation Circuit Malfunction
P0404 Exhaust Gas Recirculation Circuit Range/Performance
P0405 Exhaust Gas Recirculation Sensor A Circuit Low
P0406 Exhaust Gas Recirculation Sensor A Circuit High
P0407 Exhaust Gas Recirculation Sensor B Circuit Low
P0408 Exhaust Gas Recirculation Sensor B Circuit High
P0470 Exhaust Pressure Sensor Malfunction
P0471 Exhaust Pressure Sensor Range/Performance
P0472 Exhaust Pressure Sensor Low
P0473 Exhaust Pressure Sensor High
P0474 Exhaust Pressure Sensor Intermittent
P0475 Exhaust Pressure Control Valve Malfunction
P0476 Exhaust Pressure Control Valve Range/Performance
P0477 Exhaust Pressure Control Valve Low
P0478 Exhaust Pressure Control Valve High
P0479 Exhaust Pressure Control Valve Intermittent
Hope this article solves your doubt, have a great day!👍